PMMA Bone Cement

Makevale is a key  manufacturer and supplier of acrylic based bead polymers , a key ingredient in orthopaedic bone cements. Our material is used by many of the world’s prominent bone cement manufacturers.

In close collaboration with our bone cement clients, our researchers have formulated polymers with precise chemical and physical characteristics to work perfectly within our customers formulation. Our polymers have successfully used for new innovative products or within and existing product line where equivalence has to be proved.

What our customers say

“Makevale is a valuable and reliable supplier to us, a preferred partner and expert in their field of acrylics for medical use. They are regarded as a significant contributor to the global cemented joint replacement & patient care industry.”

A key medical device manufacturer

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  • Acrylics can be tailor made
  • Variety of pour and set times
  • Pour and set times can be modified
  • Set temperature is adaptable

PMMA Bone Cement

Many Orthopaedic bone cements have little intrinsic adhesive properties, but relies on close mechanical interlock between the irregular bone surface and the prosthesis. Consequently, the long-term chemical and physical characteristics are very important. But another crucial aspect is the polymer’s handling characteristics during mixing, working and curing.

Various additives such as antibiotics, radio opaque agents, initiators,  accelerators, inhibitors and even additives to stimulate bone growth such as hydroxyapatite, affect the handling and mechanical properties of orthopaedic bone cements.

Our ability to exercise tight control over molecular weight, residual monomer, moisture content and particle size allows us to modify handling characteristics like the viscosity profile of the bone cement as well as the injection and curing times. The polymer composition also facilitates performance properties such as the mechanical properties or even irradiation shielding.

Innovation and Research

Our advanced manufacturing technology can match clients’ precise specifications time after time. Several bone cement manufacturers have tried and failed to reproduce our particular polymer chemistry and have turned to us for reliable supply from our FDA compliant manufacturing sites.

Makevale also heavily researches new biotech initiatives. Through better material design, we strongly believe our novel nanocomposite technology will provide improved outcomes for patients. We continually assist our bone cement clients with regulatory approvals for these new classes of biotechnology products.

Success story

We conduct research in close collaboration with bone cement manufacturers; one client requested a fast-setting bone cement for a new region the customer was interested in.

After 6 months of iterative polymer formulation and testing, we arrived at the required poly methyl methacrylate bone cement formulation, which was submitted for regulatory approval.

Our Research & Development Team

If you are interested in polymers suitable for producing orthopaedic bone cement, we have a wide range of suitable acrylics and a proven track record in producing new acrylics with unique properties. If you would like to develop a new acrylic suitable for orthopaedic, bone cement, our R&D team will be interested to hear from you.

Find out more about Research and Development